30433-91-1Relevant articles and documents
Application of the cyanurate-isocyanurate rearrangement to amine synthesis: Preparation of 2-(2-thienyl)ethylamine
Harrington,Sanchez
, p. 1307 - 1314 (1993)
This communication describes a new method for preparation of 2-(2-thienyl)ethylamine, an important pharmaceutical intermediate. The method is based on the O-to-N migration of an alkyl group via cyanurate-isocyanurate rearrangment.
1,2,5-oxadiazole derivative used as indoleamine 2,3-dioxygenase inhibitor
-
, (2019/10/01)
The invention belongs to the technical field of 1,2,5-oxadiazole derivatives, and particularly relates to a 1,2,5-oxadiazole derivative or a pharmaceutically acceptable salt thereof which is used as an indoleamine 2,3-dioxygenase inhibitor. The structure of the 1,2,5-oxadiazole derivative or the pharmaceutically acceptable salt thereof used as the IDO inhibitor is shown in the following formula I.The invention provides a general formula compound I with a novel structure. Experimental results show that some compounds have excellent IDO inhibitory activity and permeation performance at the sametime. The compound is expected to be marketed as a tumor molecular immunotherapeutic drug for cancer treatment.
Hydrogenation of Nitriles and Ketones Catalyzed by an Air-Stable Bisphosphine Mn(I) Complex
Weber, Stefan,St?ger, Berthold,Kirchner, Karl
supporting information, p. 7212 - 7215 (2018/11/25)
Efficient hydrogenations of nitriles and ketones with molecular hydrogen catalyzed by a well-defined bench-stable bisphosphine Mn(I) complex are described. These reactions are environmentally benign and atomically economic, implementing an inexpensive, earth-abundant nonprecious metal catalyst. A range of aromatic and aliphatic nitriles and ketones were efficiently converted into primary amines and alcohols, respectively, in good to excellent yields. The hydrogenation of nitriles proceeds at 100 °C with catalyst loading of 2 mol % and 20 mol % base (t-BuOK), while the hydrogenation of ketones takes place already at 50 °C, with a catalyst loading of 1 mol % and 5 mol % of base. In both cases, a hydrogen pressure of 50 bar was applied.