304462-63-3

Usage

Uses

Used in Pharmaceutical Industry:
2-piperidin-4-ylbenzonitrile is utilized as a key intermediate in the synthesis of various drugs, leveraging its structural features to contribute to the development of new therapeutic agents.
Used in Antidepressant Development:
In the field of psychiatry, 2-piperidin-4-ylbenzonitrile is explored as a potential antidepressant, aiming to address the complex biochemical imbalances associated with mood disorders.
Used in Cancer Therapy:
2-piperidin-4-ylbenzonitrile is studied for its role as an enzyme inhibitor, targeting specific enzymes that play a role in the progression of cancer, thereby offering a potential therapeutic strategy against malignant diseases.
Used in Antipsychotic Medications:
2-piperidin-4-ylbenzonitrile is also investigated for its potential as an antipsychotic agent, suggesting its use in managing the symptoms of psychotic disorders by modulating neurotransmitter levels or receptor activity.
Used in Anticonvulsant Formulations:
2-piperidin-4-ylbenzonitrile is considered for its possible application in anticonvulsant medications, potentially helping to control seizures by influencing neuronal excitability.
Used in Organic Synthesis:
Beyond its direct pharmaceutical applications, 2-piperidin-4-ylbenzonitrile serves as a versatile building block in organic synthesis, enabling the creation of a wide range of chemical entities with potential applications across various industries.

Upstream product

• 766-84-7 3-chloro-benzonitrile 
• 4387-36-4 2-iodobenzonitrile 
• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 57381-37-0 2-bromo-5-chloro-benzonitrile 
• 819070-54-7 5-chloro-2-(pyridin-4-yl)benzonitrile 
• 138642-62-3 2-Cyanophenylboronic acid 
• 194669-38-0 2-[1-tert-butoxycarbonyl-(1.2.3.6-tetrahydropyridin-4-yl)]benzonitrile 
• 138647-49-1 4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 819070-53-6 (4-chloro-2-cyanophenyl)boronic acid 

Downstream Products

• 1227072-01-6 C₃₆H₄₅F₃N₆O₃S₂ 

Relevant academic research and scientific papers

PHENYL mTORC INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

(4-PHENYL-PIPERIDIN-1-YL)-[5-1H-PYRAZOL-4YL)-THIOPHEN-3-YL]-METHANONE COMPOUNDS AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain (4-phenyl-piperidin-1-yl)- [5-(1 H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds that, inter alia, inhibit 11 β-hydroxysteroid dehydrogenase type 1 (11 β-HSD1 ). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 1 1 β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11 β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.

CYCLOALKANOPYRIDINE DERIVATIVE

Provided are cycloalkanopyridine derivatives of formula [I]: [wherein the symbols are the same as those stated in the description]. The compounds act as a nociceptin receptor antagonist, and are useful as medicines for diseases associated with a nociceptin receptor, for example, as a reliever against tolerance to a narcotic analgesic; a reliever against dependence on or addiction to a narcotic analgesic; an analgesic enhancer; an antiobesitic or appetite suppressor; a treating or prophylactic agent for cognitive impairment and dementia/amnesia; an agent for treating developmental cognitive abnormality; a remedy for schizophrenia; an agent for treating neurodegenerative diseases; an anti-depressant or treating agent for affective disorder; a treating or prophylactic agent for diabetes insipidus; a treating or prophylactic agent for polyuria; or a remedy for hypotension.

An efficient synthesis of a highly functionalized 4-arylpiperidine

In this manuscript, an efficient synthesis of a functionalized 4-arylpiperidine is disclosed. Several synthetic approaches towards formation of the key aryl-piperidine sp3 carbon-carbon bond are discussed, including a scalable route to the piperidine via