30456-56-5

Upstream product

• 106-38-7 para-bromotoluene 
• 659742-21-9 (6-methylpyridin-3-yl)boronic acid 
• 116571-06-3 potassium 6-methylnicotinate 
• 3430-13-5 5-bromo-2-methylpyridine 
• 5720-05-8 4-methylphenylboronic acid 

Downstream Products

• 1062229-47-3 (S)-2-(cyclohex-2-enylmethyl)-5-p-tolylpyridine 
• 1311151-52-6 C₁₃H₁₃NO 
• 1311151-83-3 C₁₃H₁₃NO 

Relevant academic research and scientific papers

Organic electrode material and preparation method and application thereof

The invention relates to an organic electrode material and a preparation method and application thereof, and belongs to the technical field of materials. The organic electrode material belongs to conjugated carboxylate. The material is used as a working electrode of a sodium ion battery, the specific discharge capacities of an organic electrode material I-1 and an organic electrode material I-2 are 171mAh. g and 184mAh.g respectively after 100 cycles at the current density of 100mA/g, and half batteries prepared by taking I-1 and I-2 as the electrode materials can provide high specific capacity of 119mAh/g and 90mAh/g respectively in a voltage platform test process when 5C is 935mA/g. And the working voltages of the two materials both are between 0.4V and 0.7 V. The electrodematerial prepared by the method can be well applied to the sodium-ion battery, and has excellent oxidation-reduction capability and cycling stability when used as a negative electrode material. The organic electrode material is simple in preparation process and low in cost, and meets the requirement of large-scale preparation.

Cyrene as a Bio-Based Solvent for the Suzuki-Miyaura Cross-Coupling

The Suzuki-Miyaura (SM) cross-coupling is the most broadly utilized Pd-catalyzed C-C bond-forming reaction in the chemical industry. A large proportion of SM couplings employ dipolar aprotic solvents; however, current sustainability initiatives and increasingly stringent regulations advocate the use of alternatives that exhibit more desirable properties. Here we describe the scope and utility of the bio-derived solvent Cyrene in SM cross-couplings and evaluate its suitability as a reaction medium for this benchmark transformation from discovery to gram scale.

Palladium-catalyzed decarboxylative cross-coupling of 3-pyridyl and 4-pyridyl carboxylates with aryl bromides

Decarboxylative cross-coupling of 3-pyridyl and 4-pyridyl carboxylates with aryl bromides is reported. Using a bimetallic system of Cu2O and Pd(PPh3)4, the scope of the reaction is demonstrated by the synthesis of 27 pyridine-containing biaryls in moderate to good yields.

Inhibition of 1-deoxy-d-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies

1-Deoxy-d-xylulose-5-phosphate reductoisomerase (DXR) is a novel target for developing new antibacterial (including antituberculosis) and antimalaria drugs. Forty-one lipophilic phosphonates, representing a new class of DXR inhibitors, were synthesized, among which 5-phenylpyridin-2-ylmethylphosphonic acid possesses the most activity against E. coli DXR (EcDXR) with a K i of 420 nM. Structure-activity relationships (SAR) are discussed, which can be rationalized using our EcDXR:inhibitor structures, and a predictive quantitative SAR (QSAR) model is also developed. Since inhibition studies of DXR from Mycobacterium tuberculosis (MtDXR) have not been performed well, 48 EcDXR inhibitors with a broad chemical diversity were found, however, to generally exhibit considerably reduced activity against MtDXR. The crystal structure of a MtDXR:inhibitor complex reveals the flexible loop containing the residues 198-208 has no strong interactions with the 3,4-dichlorophenyl group of the inhibitor, representing a structural basis for the reduced activity. Overall, these results provide implications in the future design and development of potent DXR inhibitors.

Experimental and computational probes of a self-assembled capsule

This research was undertaken to explore the interior surface of a synthetic receptor 1.1 with arylpyridines as guests. The interior surface differentiates the guests through the recognition of their nitrogen atoms. Experimental and computational analyses revealed that there is a delicate balance of attractions and repulsions between the host and the lone pairs of guests.