304648-12-2Relevant academic research and scientific papers
Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors
Singh, Sunil K.,Reddy, P. Ganapati,Rao, K. Srinivasa,Lohray, Braj B.,Misra,Rajjak, Shaikh A.,Rao, Yeleswarapu K.,Venkateswarlu
, p. 499 - 504 (2004)
Several chemical modifications in the N1-benzenesulfonamide ring of celecoxib are presented. The series with a hydroxymethyl group adjacent to the sulfonamide was found to be the most potent modification that yielded many compounds selectively active against COX-2 enzyme in vitro.
