304663-83-0

Upstream product

• 92-92-2 biphenyl-4-carboxylic acid 
• 720-75-2 methyl 4-phenylbenzoate 
• 18622-23-6 4-phenylbenzohydrazide 
• 3132-99-8 m-bromobenzoic aldehyde 

Downstream Products

• 1222504-96-2 C₂₂H₁₇BrN₂O₂S 

Relevant academic research and scientific papers

Design and biological evaluation of biphenyl-4-carboxylic acid hydrazide-hydrazone for antimicrobial activity

Seven biphenyl-4-carboxylic acid hydrazide-hydrazones have been synthesized. These hydrazone derivatives were characterized by CHN analysis, IR, and 1H NMR spectral data. All the compounds were evaluated for their in vitro antimicrobial activity against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strain Candida albicans and Aspergillus niger. All newly synthesized compounds exhibited promising results.

Synthesis and anti-inflammatory activity of some novel biphenyl-4- carboxylic acid 5-(arylidene)-2-(aryl)-4-oxothiazolidin-3-yl amides

Some new biphenyl-4-carboxylic acid 5-(arylidene)-2-(aryl)-4- oxothiazolidin-3-yl amides have been synthesized and evaluated for anti-inflammatory activity. Biphenyl-4-carboxylic acid hydrazide was converted to the corresponding aryl hydrazones using aryl aldehydes in the presence of catalytic amount of glacial acetic acid. The aryl hydrazones on reaction with thioglycolic acid in the presence of anhydrous zinc chloride yielded the biphenyl-4-carboxylic acid 2-(aryl)-4-oxothiazolidin-3-yl amides, which again on reaction with aromatic aldehydes in the presence of anhydrous sodium acetate and glacial acetic acid furnished the title compounds. The structures of all these newly synthesized compounds were confirmed by their analytical and spectral data which were in full agreement with proposed structures. All compounds were screened for anti-inflammatory activity employing carrageenan test at the dose of 10 mg/kg and exhibited significant activities.