304674-35-9Relevant academic research and scientific papers
CHARGE REVERSIBLE POLYMERS
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Page/Page column 6-7; 3/6, (2008/06/13)
Described are charge reversible polymers, peptides and their resulting colloidal particles, comprising polymers and peptides having primary and secondary amines that are protected as easily hydrolysable amides. The amides are charge-reversible such that at neutral pH they are negatively charged but become positively charged at pH less than 6 and thus are relatively stable at neutral pH but quickly hydrolyze at pH below 6. Incorporating a drug in a micelle or a polymer comprised of the charge-reversible polymers or peptides provides a drug carrier for delivering the drug preferentially to the solid tumor or other targeted cells.
Targeted charge-reversal nanoparticles for nuclear drug delivery
Xu, Peisheng,Van Kirk, Edward A.,Zhan, Yihong,Murdoch, William J.,Radosz, Maciej,Shen, Youqing
, p. 4999 - 5002 (2008/02/10)
(Figure Presented) Reversing the charges: Targeted charge-reversal nanoparticles (TCRNs) comprised of poly(ε-caprolactone)-block- polyethyleneimine (PCL-PEI), whose amine groups are converted into amides, are negatively charged at neutral pH but become po
