304682-64-2

Upstream product

• 266338-87-8 2-[(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-2-methyl-1-oxapropyl)amino]-2,N,N-trimethylpropanamide 

Downstream Products

• 304682-52-8 2-({2-[(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-2-methyl-1-oxopropyl)amino]-2-methyl-1-oxopropyl}amino)-2,N,N-trimethylpropanamide 

Relevant academic research and scientific papers

Synthesis of conformationally restricted cyclic hexadepsipeptides via direct amide cyclization

Ring closure by direct amide cyclization was used in the synthesis of 19-membered cyclic depsipeptides 27 (Schemes 1 and 3). The linear hexapeptide precursors 4, containing the β-hydroxy acid 3-hydroxy-2-phenylpropanoic acid (Tro), and five α-amino acids of the type Aib, Gly, and Pro, were prepared according to Scheme 2. The α,α-disubstituted α-amino acid Aib was incorporated into the peptide chain via the azirine/oxazolone method, and Gly and Pro were introduced by using the TBTU/HOBt coupling method. The cyclic depsipeptides 27a-27f were obtained in reasonable-to-excellent yields (Scheme 3 and Table 1).