304693-64-9

Basic information

• Product Name: ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE
• Synonyms: ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE;5-PYRIMIDINECARBOXYLIC ACID, 2-(TRIFLUOROMETHYL)-, ETHYL ESTER;5-(Ethoxycarbonyl)-2-(trifluoromethyl)pyrimidine;Ethyl 2-(trifluoromethyl)
• CAS NO: 304693-64-9
• Molecular Formula: C₈H₇F₃N₂O₂
• Molecular Weight: 220.1485896
• Product Categories: pyrimidine;Fluorine series
• Mol File: 304693-64-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 65 °C
• Boiling Point: 194℃
• Flash Point: 71℃
• Appearance: /
• Density: 1.344
• Vapor Pressure: 0.443mmHg at 25°C
• Refractive Index: 1.448
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.50±0.22(Predicted)
• CAS DataBase Reference: ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE(304693-64-9)
• EPA Substance Registry System: ETHYL 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE(304693-64-9)

Safety Data

• Hazardous Substances Data: 304693-64-9(Hazardous Substances Data)

Usage

Uses

Ethyl 2-(Trifluoromethyl)pyrimidine-5-carboxylate is used to prepare NF-κB and AP-1 gene inhibitors.

InChI:InChI=1/C8H7F3N2O2/c1-2-15-6(14)5-3-12-7(13-4-5)8(9,10)11/h3-4H,2H2,1H3

Upstream product

• 92385-43-8 ethyl 3-(dimethylamino)-2-formylprop-2-enoate 
• 354-37-0 trifluoroacetamidine 
• 720-01-4 ethyl 2-trifluoromethyl-4-chloropyrimidine-5-carboxylate 
• 343-67-9 ethyl 2-(trifluoromethyl)-1,6-dihydro-6-oxopyrimidine-5-carboxylate 

Downstream Products

• 1192570-20-9 2-morpholin-4-yl-2-(2-trifluoromethyl-pyrimidin-5-yl)-ethylamine 
• 306960-78-1 2-trifluoromethylpyrimidine-5-carbonyl chloride 
• 306960-77-0 2-(trifluoromethyl)pyrimidine-5-carboxylic acid 

Relevant articles and documents

P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN

The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor s

Condensed pyrazole derivative

The present invention provides cyclic aminomethylpyrimidine derivatives and pharmaceutically acceptable salts thereof which show high selectivity for dopamine D4 receptors and are useful for treating diseases such as attention deficit hyperacti

P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN

The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.