Cas 304696-18-2,5-(3-benzyl-ureido)-2<i>H</i>-[1,2,4]triazole-3-carboxylic acid methyl ester

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Check Digit Verification of cas no

The CAS Registry Mumber 304696-18-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,4,6,9 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 304696-18:
(8*3)+(7*0)+(6*4)+(5*6)+(4*9)+(3*6)+(2*1)+(1*8)=142
142 % 10 = 2
So 304696-18-2 is a valid CAS Registry Number.

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304696-18-2Relevant academic research and scientific papers

Synthesis of highly potent and selective hetaryl ureas as integrin αVβ3-receptor antagonists

Lange, Udo E.W.,Backfisch, Gisela,Delzer, Juergen,Geneste, Herve,Graef, Claudia,Hornberger, Wilfried,Kling, Andreas,Lauterbach, Arnulf,Subkowski, Thomas,Zechel, Christian

, p. 1379 - 1382 (2007/10/03)

Solid-phase synthesis and SAR of integrin αVβ3-receptor antagonists containing a urea moiety as non-basic guanidine mimetic are described. The most potent compounds exhibited IC50 values towards αVβ3 in the nanomolar range and high selectivity versus related integrins like αIIbβ3. For selected examples efficacy in functional cellular assays is demonstrated.

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