304850-94-0

Upstream product

• 223595-53-7 (2S,5R)-N-(methoxycarbonyl)-5-(methyl)-2-(p-methoxyphenyl)-3-pyrroline 
• 304850-92-8 (2RS,5S)-N-(methoxycarbonyl)-5-(trityloxymethyl)-2-(p-methoxyphenyl)-3-pyrroline 
• 223595-45-7 (5S)-N-(methoxycarbonyl)-5-(trityloxymethyl)-2-pyrroline 
• 223595-51-5 (2S,5S)-2-Methanesulfonyloxymethyl-5-(4-methoxy-phenyl)-2,5-dihydro-pyrrole-1-carboxylic acid methyl ester 
• 223595-49-1 (2S,5S)-N-(methoxycarbonyl)-5-(hydroxymethyl)-2-(p-methoxyphenyl)-3-pyrroline 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 

Downstream Products

• 100100-39-8 (R,R,R,R)-N(1)-methyl-2-(4'-methoxyphenyl)-3-hydroxy-4-hydroxy-5-methylpyrroli 
• 304850-95-1 (2R,3R,4R,5R)-N-(methoxycarbonyl)-3,4-dihydroxy-5-(methyl)-2-(p-methoxyphenyl)-pyrrolidine 

Relevant academic research and scientific papers

Heck arylation of endocyclic enecarbamates with diazonium salts. Improvements and a concise enantioselective synthesis of (-)-codonopsinine.

Total enantioselective synthesis of the natural (-)-codonopsinine was accomplished in seven steps with an overall yield of approximately 16% starting from the five-membered endocyclic enecarbamate 4. The total synthesis features a highly efficient and ste