304908-48-3Relevant academic research and scientific papers
Synthesis and docking studies of pyrazine-thiazolidinone hybrid scaffold targeting dormant tuberculosis
Chitre,Asgaonkar,Miniyar,Dharme,Arkile,Yeware,Sarkar,Khedkar,Jha
, p. 2224 - 2228 (2016)
The persistence of Mycobacterium tuberculosis (MTB) in dormant stage assists the pathogen to develop resistance against current antimycobactrial drugs. To address this issue, we report herein the synthesis of N-(4-oxo-2 substituted thiazolidin-3yl) pyrazi
Synthesis andanti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives
Abdel-Aziz, Mohamed,Bdel-Rahman, Hamdy M.A.
experimental part, p. 3384 - 3388 (2010/08/13)
A series of pyrazine-2-carboxylic acid hydrazide derivatives were synthesized and screened for their activity against Mycobacterium tuberculosis. The results show that pyrazine-2-carboxylic acid hydrazi-deehydrazone derivatives 3ael were less active than pyrazinamide. In contrast,the N 4-ethyl-N1-pyr-azinoyl-thiosemicarbazide 4 showed the highest activity against M. tuberculosis H37Rv (IC90 16.87 mg/mL). Details of the structureeactivity and structureecytotoxicity relationships are discussed.
