30491-74-8

Usage

Uses

Used in Epoxy Resin Manufacturing:
3,4'-Diamino-4-nitrodiphenyl Ether is used as a curing agent for enhancing the properties of epoxy resins. It contributes to the hardening and cross-linking process, which is essential for producing strong and durable epoxy materials.
Used in Adhesives Production:
In the adhesives industry, 3,4'-Diamino-4-nitrodiphenyl Ether serves as a curing agent to improve the bonding strength and stability of adhesives. Its use ensures that the adhesives can effectively join different materials together.
Used in Coatings Industry:
3,4'-Diamino-4-nitrodiphenyl Ether is utilized as a curing agent in the production of coatings. It helps in creating coatings with improved durability, resistance to wear, and overall performance.
Used in Composites Production:
Within the composites industry, 3,4'-Diamino-4-nitrodiphenyl Ether is employed as a curing agent to facilitate the formation of strong and robust composite materials. Its role is crucial in achieving the desired mechanical properties of the composites.
Used in Electronics Applications:
3,4'-Diamino-4-nitrodiphenyl Ether is also used in the electronics sector, where it acts as a curing agent in the manufacturing of certain electronic components and devices. It ensures the reliability and longevity of these components.

InChI:InChI=1/C12H11N3O3/c13-8-1-3-9(4-2-8)18-10-5-6-12(15(16)17)11(14)7-10/h1-7H,13-14H2

Upstream product

• 29178-59-4 4-(4-acetylaminophenoxy)-2-amino-nitrobenzene 
• 1635-61-6 5-chloro-2-nitroaniline 
• 123-30-8 4-amino-phenol 
• 35719-43-8 potassium salt of 4-acetamidophenol 

Downstream Products

• 433225-93-5 5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-2-nitroaniline 
• 103248-69-7 4'-(7-chloroquinolin-4-ylamino)-3,4-diamino-diphenyl ether 
• 433225-94-6 4-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)phenylene-1,2-diamine 
• 433225-03-7 N-(6-{4-[3-(2-fluoro-5-trifluoromethyl-phenyl)-ureido]-phenoxy}-1H-benzoimidazol-2-yl)-2-(4-methyl-piperazin-1-yl)-acetamide 
• 433224-24-9 C₂₁H₁₅F₄N₅O₂ 

Relevant academic research and scientific papers

Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors

We herein disclose a novel chemical series of benzimidazole-ureas as inhibitors of VEGFR-2 and TIE-2 kinase receptors, both of which are implicated in angiogenesis. Structure-activity relationship (SAR) studies elucidated a critical role for the N1 nitrogen of both the benzimidazole (segment E) and urea (segment B) moieties. The SAR results were also supported by the X-ray crystallographic elucidation of the role of the N1 nitrogen and the urea moiety when the benzimidazole-urea compounds were bound to the VEGFR-2 enzyme. The left side phenyl ring (segment A) occupies the backpocket where a 3-hydrophobic substituent was favored for TIE-2 activity.

Chemical compounds

Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

Syntheses of 2,5(6)-Disubstituted Benzimidazoles and 1,4-Disubstituted Piperazines as Potential Antiparasitic Agents

The synthesis of a series of 5(6)-benzimidazoles (13-21), 1-(7-chloroquinolin-4-yl)-4-piperazines (29-30) and 2-substituted 5(6)-(7-chloroquinolin-4-yl