3052-06-0 Usage
General Description
1-β-D-Arabinofuranosyl-5-iodo-2,4(1H,3H)-pyrimidinedione, also known as Idoxuridine, is a synthetic nucleoside analog of deoxyuridine used in the treatment of herpes simplex virus infections, especially herpes keratitis. It works by inhibiting the viral DNA synthesis and is used as a topical antiviral agent for the treatment of herpetic keratitis, a severe form of eye herpes. Idoxuridine is administered as eye drops or ointment and is effective in reducing the duration and severity of herpes simplex virus infections. It is generally well-tolerated, but may cause mild irritation or stinging upon application. Despite its efficacy, prolonged use of idoxuridine is associated with the development of resistance and potential side effects such as corneal toxicity, and it should be used under medical supervision.
Check Digit Verification of cas no
The CAS Registry Mumber 3052-06-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,0,5 and 2 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 3052-06:
(6*3)+(5*0)+(4*5)+(3*2)+(2*0)+(1*6)=50
50 % 10 = 0
So 3052-06-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H11IN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6+,8-/m1/s1
3052-06-0Relevant articles and documents
Improved Large-scale Synthesis of 5-(Perylen-3-ylethynyl)-arabino-uridine (aUY11), the Broad-Spectrum Antiviral
Chistov, Alexey A.,Kutyakov, Sergey V.,Guz, Arsentiy V.,Mikhura, Irina V.,Ustinov, Alexey V.,Korshun, Vladimir A.
, p. 377 - 381 (2017)
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Synthesis of 5-radioiodoarabinosyl uridine analog for probing the HSV-1 thymidine kinase gene
Lin, Kun-I.,Chiang, Li-Wu,Wu, Chien-Hung,Chen, Shao-Wei,Yu, Chung-Shan
, p. 563 - 568 (2008/02/10)
Tumor cells transduced with herpes simplex virus thymidine kinase gene have been intensively applied to the field of positron emission tomography via imaging of its substrate. As a pilot synthesis approach, a facile preparation of 5-[125I]iodoarabinosyl uridine starting from commercially available uridine is reported herein.
Anti-HCV nucleoside derivatives
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, (2008/06/13)
The present invention comprises novel and known purine and pyrimidine nucleoside derivatives which have been discovered to be active against hepatitis C virus (HCV). The use of these derivatives for the treatment of HCV infection is claimed as are the novel nucleoside derivatives disclosed herein.
