30530-97-3 Usage
Uses
Used in Pharmaceutical Development:
(4-OXO-3-PHENYL-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID is used as a potential therapeutic agent for the development of pharmaceutical drugs due to its demonstrated inhibitory activity against different enzymes and receptors. Its unique structure allows for diverse interactions with biological targets, which could lead to the creation of novel treatments for various medical conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (4-OXO-3-PHENYL-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID is used as a subject of study for its potential to interact with various biological targets. This research could contribute to the understanding of its pharmacological properties and the development of new drugs based on its structure and activity.
Used in Drug Design and Optimization:
(4-OXO-3-PHENYL-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID is used as a starting point for drug design and optimization efforts. Its unique chemical structure and demonstrated biological activity make it a valuable compound for the development of new drugs with improved efficacy, selectivity, and safety profiles.
Used in Enzyme and Receptor Inhibition Studies:
In the context of enzyme and receptor inhibition, (4-OXO-3-PHENYL-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID is used as a research tool to investigate its potential as an inhibitor of specific enzymes and receptors. This information can be crucial for understanding the compound's mechanism of action and its potential therapeutic applications.
Used in Drug Delivery Systems:
Similar to gallotannin, (4-OXO-3-PHENYL-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID could be used in the development of novel drug delivery systems to enhance its applications and efficacy. Various organic and metallic nanoparticles could be employed as carriers for (4-OXO-3-PHENYL-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID, aiming to improve its delivery, bioavailability, and therapeutic outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 30530-97-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,5,3 and 0 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 30530-97:
(7*3)+(6*0)+(5*5)+(4*3)+(3*0)+(2*9)+(1*7)=83
83 % 10 = 3
So 30530-97-3 is a valid CAS Registry Number.
30530-97-3Relevant academic research and scientific papers
Molecular modeling studies and synthesis of novel methyl 2-(2-(4-Oxo-3-aryl-3,4-dihydroquinazolin-2-ylthio)acetamido)alkanoates with potential anti-cancer activity as inhibitors for methionine synthase
Elfekki, Ismail Mahmoud,Hassan, Walid Fathalla Mohamed,Elshihawy, Hosam Eldin Abd Elhamed,Ali, Ibrahim Ahmed Ibrahim,Eltamany, Elsayed Hussein Mostafa
, p. 675 - 694 (2014/08/05)
Cobalamin-dependant cytosolic enzyme methionine synthase (MetS) catalyses the transfer of a methyl group from the methyltetrahydrofolate (MTHF) to homocysteine (Hcy) to produce methionine and tetrahydrofolate (THF). MetS is over-expressed in the cytosol of certain breast and prostate tumour cells. Methionine used as a source of one carbon atom for the building of the DNA of the tumour cells, structural protein and enzymes. In this study, we designed, synthesized and evaluated the cytotoxic activity of a series of substituted methyl 2-(2-(4-oxo-3-aryl-3,4-dihydroquinazolin-2-ylthio)acetamido)acetate and dipeptide that mimic the substructure of MTHF. These inhibitors were docked in to the MTHF binding domain in such the same way as MTHF in its binding domain. The free energies of the binding were calculated and compared to the IC 50 values. This series has been developed by dicyclohexylcarbodiimide (DCC) and azide coupling methods of amino acid esters with carboxylic acid derivatives, respectively. Compound methyl 3-hydroxy-2-(2-(3-(4-methoxyphenyl)- 4-oxo-3,4-dihydroquinazolin-2-ylthio)acetamido)propanoate exhibited the highest IC50 value 20 μg/mL against PC-3 cell line and scored the lowest free energy of the binding (-07.19 kJ/mol).
