305360-85-4Relevant academic research and scientific papers
A novel and efficient route for the synthesis of 5-nitrobenzo[d]oxazole derivatives
Vosooghi, Mohsen,Arshadi, Hossein,Saeedi, Mina,Mahdavi, Mohammad,Jafapour, Farnaz,Shafiee, Abbas,Foroumadi, Alireza
, p. 83 - 86 (2014)
In this paper, we report a novel and efficient route for the synthesis of 5-nitrobenzoxazole derivatives starting from 2-fluoro-5-nitroaniline and various benzoyl chloride derivatives under solvent-free conditions at 130 °C in the presence potassium carbonate. Benzoyl chlorides easily underwent nucleophilic acyl substitution followed by intramolecular cyclization via concomitant removal of fluorine to obtain the title compounds in high yields.
