305367-57-1

Upstream product

• 305367-56-0 1,2-bis-(3-azido-prop-1-ynyl)-benzene 
• 116510-02-2 1,2-bis(3-hydroxyprop-1-yn-1-yl)benzene 
• 116510-22-6 1,2-bis(1-methylsulfonyloxyprop-1-yn-1-yl)benzene 
• 583-53-9 2,3-dibromobenzene 
• 330595-68-1 1,2-bis-(1-phthalimidoprop-2-ynyl) benzene 
• 1400590-78-4 {3-[2-(3-tert-butoxycarbonylamino-prop-1-ynyl)phenyl]prop-2-ynyl}carbamic acid tert-butyl ester 

Downstream Products

• 330595-63-6 1,2-bis-(4-N-tert-butoxycarbonylaminomethylbenzylcarbonyl-1-aminoprop-2-ynyl)-benzene 
• 1400590-79-5 2-bromo-N-(3-{2-[3-(2-bromoacetylamino)prop-1-ynyl]phenyl}prop-2-ynyl)acetamide 
• 1400590-82-0 C₃₆H₄₀N₆O₁₀ 
• 1400590-83-1 2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-N-[3-(2-{3-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)acetylamino]prop-1-ynyl}phenyl)prop-2-ynyl]acetamide 

Relevant academic research and scientific papers

Synthesis and reactivity of enediyne-nucleobase hybrids: Effect of intramolecular π-stacking

Three distinct classes of nucleobase-containing enediynes 1-9 with varying nature of the linker have been synthesized to explore the effect of π-stacking interaction in accelerating the rate of Bergman cyclization (BC). Chemical reactivity study, both experimental and computations demonstrated the important role that aromatic π-stacking interactions between the appended nucleobases within an enediyne frame play in lowering the activation barrier of Bergman cyclization.

Tryptase inhibitors

Compounds of formula (I) in which M, B1, B2, B3, B4, B5, B6, A1, A2, A3, A4, A5, A6, K1 and K2 have the meanings as indicated in the description, are novel effective tryptase inhibitors.

Synthesis and thermal reactivity of a novel bis-salicylaldimino enediyne and its Cu(II) and Ni(II) complexes

A novel bis-salicylaldimino enediyne 1, along with its Ni(II) and Cu(II) complexes 6 and 7, respectively, were prepared. Differential Scanning Calorimetric studies revealed an elevation of the onset temperature for Bergman cyclization upon complexation. (