305371-21-5

Basic information

• Product Name: 6-amino-4-(3-bromo-phenylamino)-[1.7]naphthyridine-3-carbonitrile
• Synonyms: 6-amino-4-(3-bromo-phenylamino)-[1.7]naphthyridine-3-carbonitrile
• CAS NO: 305371-21-5
• Molecular Weight: 340.182
• Mol File: 305371-21-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-amino-4-(3-bromo-phenylamino)-[1.7]naphthyridine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-4-(3-bromo-phenylamino)-[1.7]naphthyridine-3-carbonitrile(305371-21-5)
• EPA Substance Registry System: 6-amino-4-(3-bromo-phenylamino)-[1.7]naphthyridine-3-carbonitrile(305371-21-5)

Safety Data

• Hazardous Substances Data: 305371-21-5(Hazardous Substances Data)

Upstream product

• 305371-19-1 4-(3-bromo-phenylamino)-6-fluoro-[1.7]naphthyridine-3-carbonitrile 
• 1827-27-6 2-fluoro-5-aminopyridine 
• 4548-45-2 2-chloro-5-nitropyridine 
• 456-24-6 2-Fluoro-5-nitropyridine 
• 305371-20-4 4-(3-bromo-phenylamino)-6-(4-methoxy-benzylamino)-[1.7]naphthyridine-3-carbonitrile 

Relevant articles and documents

Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles

The syntheses and EGFR kinase inhibitory activity of a series of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles are described. Both reversible and irreversible binding inhibitors were prepared. These series were compared with each other and with the corresponding 4-anilinoquinoline-3-carbonitriles. Compounds having a 1,7-naphthyridine core structure can retain high potency while those with a 1,8-naphthyridine core are significantly less active. These results are consistent with molecular modeling observations.

SUBSTITUTED 3-CYANO-[1.7], [1.5] AND [1.8] NAPHTHYRIDINE INHIBITORS OF TYROSINE KINASES

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