305372-80-9Relevant academic research and scientific papers
An efficient tetrabutylammonium fluoride (TBAF)-catalyzed three-component synthesis of 3-substituted indole derivatives under solvent-free conditions
Singh, Neetu,Allam, Bharat Kumar,Raghuvanshi, Dushyant Singh,Singh, Krishna Nand
, p. 1840 - 1848 (2013)
An expedient and efficient one-pot three-component synthesis of 3-substituted indoles has been developed by the reaction of indoles, active methylene compounds and aldehydes using a catalytic amount of tetrabutylammonium fluoride under solvent-free conditions. Copyright
Water assisted and choline chloride-dimethylurea deep eutectic salts as catalyst towards the attractive reaction of indole, benzaldehyde, and malononitrile
Ruan, Hongli,Lv, Yue,Yu, Shijun,Lv, Chengwei,An, Yue
, p. 1266 - 1274 (2018/08/06)
The condensation of indole, benzaldehyde, and malononitrile was relatively rigorous compared with other Yonemitsu type reaction. We described a strategy using catalytic amount of choline chloride-dimethylurea deep eutectic salts as cheap and safe accelerator. We also found that introducing right amount of water in reaction system was crucial. This method tolerates variations in all three components to get desired 3-substituted indoles in satisfactory yields.
Polyethylene glycol (PEG-200)-promoted sustainable one-pot three-component synthesis of 3-indole derivatives in water
Wang, Leilei,Huang, Manna,Zhu, Xinhai,Wan, Yiqian
, p. 160 - 163 (2013/08/25)
A sustainable three-component reaction of indoles, aldehydes, and malononitrile in water promoted by polyethylene glycol (PEG-200) afforded 3-indole derivatives in good to excellent yields.
A ligand-free copper(II)-catalyzed three-component reaction in poly(ethylene glycol) medium: A versatile protocol for the preparation of selected 3-indole derivatives
Chandrasekhar, Srivari,Patro, Vidyavathi,Reddy, Gangireddy Pavan Kumar,Gree, Rene
supporting information, p. 6223 - 6225,3 (2012/12/11)
An efficient and eco-friendly method has been developed for the synthesis of selected 3-indole derivatives via a copper-catalyzed condensation between indole, aldehydes, and malononitrile in polyethylene glycol. The reagent system (PEG solvent plus cataly
Synthesis of 3-indole derivatives by copper sulfonato Salen catalyzed three-component reactions in water
Qu, Yanyang,Ke, Fang,Zhou, Li,Li, Zhengkai,Xiang, Haifeng,Wu, Di,Zhou, Xiangge
supporting information; experimental part, p. 3912 - 3914 (2011/05/04)
An efficient three-component reaction of indole, aldehyde, and malononitrile in water catalyzed by a copper(ii) sulfonato Salen complex afforded 3-indole derivatives in good to excellent yields up to 97%. The Royal Society of Chemistry.
