30560-61-3

Upstream product

• 108-94-1 cyclohexanone 
• 95-48-7 ortho-cresol 
• 576-26-1 2.6-dimethylphenol 

Downstream Products

• 1239517-09-9 2,2'-(4,4'-(cyclohexane-1,1-diyl)bis(2,6-dimethyl-4,1-phenylene))bis(oxy)bis(methylene)dioxirane 

Relevant academic research and scientific papers

Macrocyclic ethers and their inclusion complexes

The synthesis and characterisation of eleven new macrocyclic ethers (up to 96-membered [6+6] gigantocycle) with well-defined cavities are described. Syntheses of the macrocycles M1-M7 were performed under high-dilution conditions. A 'supramolecular' purif

An improved, highly efficient method for the synthesis of bisphenols

An efficient synthesis of bisphenols is described by condensation of substituted phenols with corresponding cyclic ketones in presence of cetyltrimethylammonium chloride and 3-mercaptopropionic acid as a catalyst in extremely high purity and yields. Copyright E-Journal of Chemistry 2004-2011.

Structural optimization and biological evaluation of substituted bisphenol a derivatives as β-amyloid peptide aggregation inhibitors

The aggregation of A? is a crucial step in the etiology of Alzheimer's disease. Our previous work showed that A? undergoes ?-helix/?-sheet intermediate structures during the conformational transition, and an A? aggregation inhibitor (1) was discovered by targeting the intermediates. Here, structure optimization toward compound 1 was performed and 34 novel derivatives were designed and synthesized. Nine compounds showed more effective inhibitory activity than the hit compound 1 in ThT fluorescence assay. Among them, compound 43 demonstrated more excellent inhibitory potency, which not only can suppress the aggregation of A? but also can dissolve the preformed fibrils as shown by CD spectroscopy, PICUP and AFM assays. Cellular assay indicated that 43 has no toxicity to neuronal cells, moreover, can effectively inhibit A? 1?42-induced neutrotoxicity and increase the cell viability. Together, on the basis of these positive results, these novel chemical structures may provide a promising potential for therapeutic applications in AD and other types of neurodegenerative disorders.

METHOD FOR PURIFYING 1,1-BIS(4'-HYDROXY-3'-METHYLPHENYL)CYCLOHEXANE AND METHODS OF PRODUCING POLYCARBONATES THEREFROM

A method for purifying 1,1-bis(4'-hydroxy-3'-methylphenyl)cyclohexane comprises dissolving said 1,1-bis(4'-hydroxy-3'-methylphenyl)cyclohexane in a first solvent consisting essentially of an alcohol to form a first solution; filtering said first solution; adding a second solvent consisting essentially of water to the filtered first solution to form a second solution, wherein said second solution comprises about 40 parts to about 95 parts of the first solvent per 100 parts of the combined weight of the first and second solvents; crystallizing said 1,1-bis(4'-hydroxy-3'-methylphenyl)cyclohexane from said second solution to form a first crystalline product; dissolving said first crystalline product in a third solvent to form a third solution, wherein the third solvent comprises an aromatic compound; and crystallizing said 1,1-bis(4'-hydroxy-3'-methylphenyl)cyclohexane from said third solution to produce a second crystalline product.

Bisphosphine oxide monomers

Bisphosphine oxide monomers and homologs thereof may be incorporated into polycarbonates in order to obtain a flame retardant polymer. More particularly, bis[2,5-(diphenylphosphine oxide)]-1,4-hydroquinone and homologs thereof may be used to prepare flame retardant polycarbonates that retain high glass transition temperature and high impact resistances.