3058-68-2Relevant academic research and scientific papers
Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer
Tang, Chu,Li, Changhao,Zhang, Silong,Hu, Zhiye,Wu, Jun,Dong, Chune,Huang, Jian,Zhou, Hai-Bing
supporting information, p. 4550 - 4572 (2015/06/25)
A strategy to develop chemotherapeutic agents by combining several active groups into a single molecule as a conjugate that can modulate multiple cellular pathways may produce compounds having higher efficacy compared to that of single-target drugs. In th
Development of Selective Estrogen Receptor Modulator (SERM)-Like Activity Through an Indirect Mechanism of Estrogen Receptor Antagonism: Defining the Binding Mode of 7-Oxabicyclo[2.2.1]hept-5-ene Scaffold Core Ligands
Zheng, Yangfan,Zhu, Manghong,Srinivasan, Sathish,Nwachukwu, Jerome C.,Cavett, Valerie,Min, Jian,Carlson, Kathryn E.,Wang, Pengcheng,Dong, Chune,Katzenellenbogen, John A.,Nettles, Kendall W.,Zhou, Hai-Bing
scheme or table, p. 1094 - 1100 (2012/07/31)
Previously, we discovered estrogen receptor (ER) ligands with a novel three-dimensional oxabicyclo[2.2.1]heptene core scaffold and good ER binding affinity act as partial agonists via small alkyl ester substitutions on the bicyclic core that indirectly mo
