305822-56-4Relevant academic research and scientific papers
Discovery of potent, nonsteroidal, and highly selective glucocorticoid receptor antagonists
Morgan, Bradley P.,Swick, Andrew G.,Hargrove, Diane M.,LaFlamme, Janet A.,Moynihan, Melinda S.,Carroll, Richard S.,Martin, Kelly A.,Lee, Eunsun,Decosta, Debra,Bordner, Jon
, p. 2417 - 2424 (2002)
An approach to the computer-assisted, pharmacophore design of nonsteroidal templates for the glucocorticoid receptor (GR) that contained an element of pseudo-C2 symmetry was developed. The enatiomer of the initial design, 1Ra, and not the designed molecul
