305849-47-2Relevant academic research and scientific papers
Efficient synthesis of esermethole and its analogues
Zhou, Yongyun,Zhao, Yuanhong,Dai, Xiaoyong,Liu, Jianping,Li, Liang,Zhang, Hongbin
, p. 4091 - 4097 (2011)
In this work, a general and flexible synthetic route towards the synthesis of pyrroloindoline alkaloids was developed. This new strategy features with a palladium mediated sequential arylation-allylation of o-bromoanilides and leads to the construction of oxindoles bearing a full carbon quaternary center. The cheap triphenylphosphine was proved to be a highly effective ligand for this one pot transformation. On the basis of this new method, esermethole and its analogues were synthesized.
