30608-81-2Relevant academic research and scientific papers
Synthesis, Characterization, and Anticancer Activity of New Benzofuran Substituted Chalcones
Co?kun, Demet,Tekin, Suat,Sandal, Süleyman,Co?kun, Mehmet Fatih
, (2016/08/13)
Benzofuran derivatives are of great interest in medicinal chemistry and have drawn considerable attention due to their diverse pharmacological profiles including anticancer activity. Similarly, chalcones, which are common substructures of numerous natural products belonging to the flavonoid class, feature strong anticancer properties. A novel series of chalcones, 3-aryl-1-(5-bromo-1-benzofuran-2-yl)-2-propanones propenones (3a-f), were designed, synthesized, and characterized. In vitro antitumor activities of the newly synthesized (3a-f) and previously synthesized (3g-j) chalcone compounds were determined by using human breast (MCF-7) and prostate (PC-3) cancer cell lines. Antitumor properties of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell viability assay for the tested chalcone compounds was performed and the log I C 50 values of the compounds were calculated after 24-hour treatment. Our results indicate that the tested chalcone compounds show antitumor activity against MCF-7 and PC-3 cell lines (p 0.05).
3-(substituted Aryl)-1-benzofuranyl-2-propenones: Antimicrobial properties of some chalcones-type compounds and their 2-pyrazoline derivatives
Coskun, Demet,Ahmedzade, Misir,Kirbag, Sevda
experimental part, p. 1574 - 1581 (2012/05/07)
2-Acetylbenzofuran on condensation with furan-2-carboxaldehyde and pyrrole-2-carboxaldehyde in methanolic KOH solution yielded the corresponding benzofuran chalcones. These two compounds and nine benzofuran chalcones were synthesized before, were further
Design, synthesis, and antitubercular evaluation of novel series of 3-benzofuran-5-aryl-1-pyrazolyl-pyridylmethanone and 3-benzofuran-5-aryl-1- pyrazolylcarbonyl-4-oxo-naphthyridin analogs
Manna, Kuntal,Agrawal, Yadvendra K.
experimental part, p. 3831 - 3839 (2010/09/11)
Twenty-eight newer 3-benzofuran-5-aryl-1-pyrazolyl-pyridylmethanone and 3-benzofuran-5-aryl-1-pyrazolylcarbonyl-4-oxo-naphthyridin analogs were synthesized by microwave irradiation method and evaluated for in-vitro and in-vivo antitubercular activity agai
