30613-53-7

Basic information

• Product Name: (Z)-3-(trifluoromethyl)-4-(2-(3-(trifluoromethyl)phenyl)hydrazono)-1H-pyrazol-5(4H)-one
• Synonyms: (Z)-3-(trifluoromethyl)-4-(2-(3-(trifluoromethyl)phenyl)hydrazono)-1H-pyrazol-5(4H)-one
• CAS NO: 30613-53-7
• Molecular Weight: 324.185
• Mol File: 30613-53-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (Z)-3-(trifluoromethyl)-4-(2-(3-(trifluoromethyl)phenyl)hydrazono)-1H-pyrazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-(trifluoromethyl)-4-(2-(3-(trifluoromethyl)phenyl)hydrazono)-1H-pyrazol-5(4H)-one(30613-53-7)
• EPA Substance Registry System: (Z)-3-(trifluoromethyl)-4-(2-(3-(trifluoromethyl)phenyl)hydrazono)-1H-pyrazol-5(4H)-one(30613-53-7)

Safety Data

• Hazardous Substances Data: 30613-53-7(Hazardous Substances Data)

Upstream product

• 34648-94-7 m-trifluoromethyldiazonium chloride 
• 401-73-0 5-trifluoromethyl-2,4-dihydropyrazol-3-one 

Downstream Products

• 944539-59-7 tricarbonyl(4-(3-trifluoromethylphenylhydrazono)-5-trifluoromethyl-2,4-dihydropyrazol-3-one)ruthenium 

Relevant articles and documents

3-Trifluoromethylpyrazolones derived nucleosides: Synthesis and antiviral evaluation

Dengue (DENV) viral infection is a global public health problem that infrequently develops life threatening diseases such as dengue hemorrhagic fever (DFS) and dengue shock syndrome (DSS). Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic human corona virus with 38% fatality rate of infected patients. A series of 4-arylhydrazono-5-trifluoromethyl-pyrazolones, their ribofuranosyl, and 5′-deoxyribofuranosyl nucleosides were synthesized, geometry optimized using Density functional theory (DFT), and evaluated for their antiviral activity. 2-Nitrophenylhydrazonopyra-zolone derivative 5 showed significant activity against MERS-CoV (EC50 = 4.6 μM). The nucleoside analog 8 showed moderate activity against DENV-2 (EC50 = 10 μM), while the activity was abolished with the corresponding 5′-deoxyribonucleoside analogs. The identified hits in this study set this category of compounds for further future optimizations.