30628-31-0Relevant academic research and scientific papers
Synthesis method of substituted phenol
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Paragraph 0084; 0096, (2020/09/16)
The invention provides a synthesis method of substituted phenol. The target product substituted phenol is prepared by taking substituted benzene as an initial raw material, and the whole synthetic process is high in selectivity, high in yield, convenient to operate and high in atom economy.
Negishi cross-coupling of secondary alkylzinc halides with aryl/heteroaryl halides using Pd-PEPPSI-IPent
Alimsiz, Seluk,Organ, Michael G.
supporting information; experimental part, p. 5181 - 5183 (2011/06/09)
Pd-PEPPSI-IPent has proven to be an excellent catalyst for the Negishi cross-coupling reaction of secondary alkylzinc reagents with a wide variety of aryl/heteroaryl halides. Importantly, β-hydride elimination/migratory insertion of the organometallic leading to the production of isomeric coupling products has been significantly reduced using the highly-hindered Ipent ligand.
Negishi coupling of secondary alkylzinc halides with aryl bromides and chlorides
Han, Chong,Buchwald, Stephen L.
supporting information; experimental part, p. 7532 - 7533 (2009/10/16)
(Chemical Equation Presented) An efficient palladium-catalyzed process has been developed for Negishi coupling of secondary alkylzinc halides with a wide range of aryl bromides and activated aryl chlorides. A palladium catalyst composed of a new biaryldialkylphosphine ligand, CPhos, effectively promotes the rate of the reductive elimination step relative to the rate of the undesired β-hydride elimination. The broad substrate scope and excellent ratio of the desired secondary to the undesired primary coupling product make this method a powerful and reliable tool forC(sp3)-C(sp2) bond formation.
