306296-77-5

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 5804-85-3 diethylaluminium cyanide 
• 147081-29-6 (S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 306298-07-7 4-[1-cyano-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 306298-17-9 4-[1-cyano-1-(4-trifluoromethyl-phenyl)-but-3-enyl]-3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 696600-46-1 (4,6-Dimethyl-pyrimidin-5-yl)-(4-methyl-4-{(S)-3-methyl-4-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazin-1-yl}-piperidin-1-yl)-methanone 
• 306298-10-2 4-Methyl-4-{(S)-3-methyl-4-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazin-1-yl}-piperidine-1-carboxylic acid tert-butyl ester 
• 306298-11-3 (S)-2-Methyl-4-(4-methyl-piperidin-4-yl)-1-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine 
• 306298-08-8 (S)-3-Methyl-4-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 306298-09-9 (S)-2-Methyl-1-[(S)-2-phenyl-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine 

Relevant academic research and scientific papers

Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. IV. Discovery of 1-[(4,6-Dimethyl-5-pyrimidinyl) carbonyl]-4-[4-{2-methoxy-1(R)-4-(trifluoromethyl)-phenyl}ethyl-3(S) -methyl-1-piperazinyl]-4-methylpiperidine (Sch-417690/Sch-D), a Potent, Highly Sel

The nature and the size of the benzylic substituent are shown to be the key to controlling receptor selectivity (CCR5 vs M1, M2) and potency in the title compounds. Optimization of the lead benzylic methyl compound 3 led to the methoxymethyl analogue 30,

Piperazine derivatives useful as CCR5 antagonists

The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1is hydrogen or alkyl; R2is substituted phenyl, substituted heter