3063-60-3Relevant academic research and scientific papers
Method for preparing bi (2-micristin) calcium urea compound
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Paragraph 0019; 0024; 0025, (2017/03/24)
The invention belongs to the technical field of drug synthesis and particularly relates to a method for preparing a bi (2-micristin) calcium urea compound.The method includes the steps that an acetylsalicylic acid compound (III) is added to aqueous suspension of calcium carbonate in a stirring condition, a reaction is conducted, and an acetylsalicylic acid calcium compound (II) is obtained; urea is added without separation for a complex reaction, reaction mixed liquid is subjected to filter pressing and decompression concentration, and a crude product of a bi (2-micristin) calcium urea compound (I) is obtained; posttreatment is conducted, and a fine product of the bi (2-micristin) calcium urea compound (I) is obtained.The method is stable in process, mild in reaction condition, easy to control, short in production cycle, low in energy consumption, high in yield and stable in product quality, the HPLC content is 99.8% and above, and the single biggest impurity salicylic acid is smaller than 0.1%, posttreatment is simple and convenient, recycled solvent can be continuously applied mechanically, waste gas, wastewater and solid waste are less, production cost is low, and the method is suitable for industrial production.
