306314-14-7

Upstream product

• 219953-66-9 (2R,3S)-2-(N-carbobenzoxy)amino-1,1,1-trifluoro-hex-5-en-3-ol 

Downstream Products

• 306314-17-0 (S)-2-((3S,4R)-4-Benzyloxycarbonylamino-5,5,5-trifluoro-3-hydroxy-pentanoylamino)-propionic acid methyl ester 
• 306314-21-6 (3S,4R)-5,5,5-Trifluoro-3-hydroxy-4-[(S)-2-((3S,4R)-5,5,5-trifluoro-3-hydroxy-4-{(S)-3-methyl-2-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-butyrylamino}-pentanoylamino)-propionylamino]-pentanoic acid methyl ester 
• 306314-19-2 (3S,4R)-4-[(S)-2-((3S,4R)-4-Benzyloxycarbonylamino-5,5,5-trifluoro-3-hydroxy-pentanoylamino)-propionylamino]-5,5,5-trifluoro-3-hydroxy-pentanoic acid methyl ester 
• 306314-18-1 (S)-2-((3S,4R)-4-Benzyloxycarbonylamino-5,5,5-trifluoro-3-hydroxy-pentanoylamino)-propionic acid 
• 306314-15-8 (3S,4R)-4-Benzyloxycarbonylamino-5,5,5-trifluoro-3-hydroxy-pentanoic acid methyl ester 

Relevant academic research and scientific papers

Total synthesis of a Pepstatin analogue incorporating two trifluoromethyl hydroxymethylene isosteres

The total synthesis of a trifluoromethyl (Tfm) analogue of the aspartate protease inhibitor Pepstatin has been accomplished via incorporation of two α-Tfm-amino β-hydroxy peptide isosteres instead of the natural statine units. The title compound as well as several Tfm-substituted precursors did not show anti-HIV activity. (C) 2000 Elsevier Science Ltd.