30646-49-2

Basic information

• Product Name: 2-AMINO-N-(TETRAHYDRO-FURAN-2-YLMETHYL)-BENZAMIDE
• Synonyms: AKOS BBB/059;2-AMINO-N-(TETRAHYDRO-FURAN-2-YLMETHYL)-BENZAMIDE;benzamide, 2-amino-N-[(tetrahydro-2-furanyl)methyl]-;2-amino-N-((tetrahydrofuran-2-yl)methyl)benzamide hydrochloride;2-amino-N-(2-tetrahydrofuranylmethyl)benzamide hydrochloride;2-amino-N-(oxolan-2-ylmethyl)benzamide hydrochloride;2-amino-N-(tetrahydrofuran-2-ylmethyl)benzamide hydrochloride;2-amino-N-(tetrahydrofurfuryl)benzamide hydrochloride
• CAS NO: 30646-49-2
• Molecular Formula: C₁₂H₁₆N₂O₂
• Molecular Weight: 220.27
• Mol File: 30646-49-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 442.9°Cat760mmHg
• Flash Point: 221.7°C
• Appearance: /
• Density: 1.172g/cm³
• Vapor Pressure: 4.84E-08mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: 2-AMINO-N-(TETRAHYDRO-FURAN-2-YLMETHYL)-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-(TETRAHYDRO-FURAN-2-YLMETHYL)-BENZAMIDE(30646-49-2)
• EPA Substance Registry System: 2-AMINO-N-(TETRAHYDRO-FURAN-2-YLMETHYL)-BENZAMIDE(30646-49-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 30646-49-2(Hazardous Substances Data)

Usage

Structure

Benzamide derivative with an amino group and a tetrahydrofuran ring attached to the benzene ring

Potential applications

Medicinal chemistry, pharmaceutical development

Use

Valuable intermediate for synthesis of bioactive compounds and drug candidates

Potential impact

Discovery of new drugs with therapeutic benefits

InChI:InChI=1/C12H16N2O2/c13-11-6-2-1-5-10(11)12(15)14-8-9-4-3-7-16-9/h1-2,5-6,9H,3-4,7-8,13H2,(H,14,15)/t9-/m1/s1

Upstream product

• 4795-29-3 TETRAHYDROFURFURYLAMINE 
• 118-48-9 isatoic anhydride 

Downstream Products

• 923841-22-9 2-phenyl-3-((tetrahydrofuran-2-yl)methyl)-2,3-dihydroquinazolin-4(1H)-one 

Relevant articles and documents

Simple and Efficient Amberlite 15-catalyzed Synthesis of Dihydroquinazolinones

Abstract: The Amberlite 15 catalyzed synthesis of substituted 2,3-dihydroquinazolin-4(1H)-ones was reported. The reaction conditions were optimized by screening in different solvents and catalysts. The substrate scope of the reaction was also studied, and

Synthesis and in vitro study of platelet antiaggregant activity of some 4-quinazolinone derivatives

Some new 4-quinazolinones were prepared. Their antiplatelet activity was evaluated in vitro with respect to aggregation induced by ADP, collagen, arachidonic acid and the platelet serotonin release reaction. Most molecules showed an inhibiting power similar to that of acetylsalicylic acid under the same conditions, and even greater when aggregation was induced by ADP. Reduction of the 4-quinazolinone derivatives to their 1,2,3,4-tetrahydroquinazoline homologues produced an increase in platelet inhibitory action except when ADP is the inductor.