306740-66-9

Basic information

• Product Name: (1R)-2β-(1-propanoyl)-3α-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane
• Synonyms: (1R)-2β-(1-propanoyl)-3α-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane
• CAS NO: 306740-66-9
• Molecular Weight: 326.266
• Mol File: 306740-66-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1R)-2β-(1-propanoyl)-3α-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-2β-(1-propanoyl)-3α-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane(306740-66-9)
• EPA Substance Registry System: (1R)-2β-(1-propanoyl)-3α-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane(306740-66-9)

Safety Data

• Hazardous Substances Data: 306740-66-9(Hazardous Substances Data)

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 192461-06-6 O-1157 
• 306740-64-7 (1R)-2β-carboxylic acid methoxymethylamide-3α-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane 
• 211046-98-9 O-1109 
• 168143-65-5 methyl (1R,5S)-8-methyl-3-(((trifluoromethyl)sulfonyl)oxy)-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate 
• 85506-18-9 (1R)-(-)-2-carbomethoxy-3-tropinone 

Downstream Products

• 306740-70-5 N-[2-(3'-N'-propyl-(1''R)-3''α-(3,4-dichlorophenyl)tropane-2''β-(1-propanoyl))((2-((triphenylmethyl)thio)ethyl)amino)acetyl]-S-(triphenyl)-2-aminoethanethiol 
• 306740-68-1 (1R)-2β-(1-propanoyl)-3α-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane 

Relevant articles and documents

Therapeutic tropane compounds

This invention relates to therapeutic uses of boat tropane analogs, e.g, treatment of neurodegenerative disorders. More specifically the invention relates to a method of treating a neurological disorder in patient comprising administering to the patient an effective amount of a boat tropane compound.

Intermediates for the synthesis of radiolabelled tropanes

The compounds of the present invention comprise a tropane compound or ligand that selectively binds to tropane recognition sites, e.g., neuron transporters such as that DAT. The tropane ligand is radiolabeled with a radioactive technetium or rhenium by a chelating ligand which is attached to the tropane ligand by a linker. Tropane compounds or ligands useful in the pratice of the present invention can generally be represented by formula II where R1 and R2 are defined as above and where R1 can also be substituted at the C4 position of the tropane ring: Any tropane compound of the general formula II is useful in the present invention so long as it binds to DAT. Useful tropane analogs have a 3α-group,i.e., are of the boat configuration. Intermediates for the synthesis of the radiolabeled tropanes are claimed.