306740-86-3Relevant academic research and scientific papers
A second-generation 99mtechnetium single photon emission computed tomography agent that provides in vivo images of the dopamine transporter in primate brain
Meltzer, Peter C.,Blundell, Paul,Zona, Thomas,Yang, Lihua,Huang, Hong,Bonab, Ali A.,Livni, Eli,Fischman, Alan,Madras, Bertha K.
, p. 3483 - 3496 (2007/10/03)
The dopamine transporter (DAT), located presynaptically on dopamine neurons, provides a marker for Parkinson's disease (Pd) and attention deficit hyperactivity disorder (ADHD). In ADHD, DAT density levels are elevated, while in Pd these levels are deplete
Intermediates for the synthesis of radiolabelled tropanes
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Page 24, (2008/06/13)
The compounds of the present invention comprise a tropane compound or ligand that selectively binds to tropane recognition sites, e.g., neuron transporters such as that DAT. The tropane ligand is radiolabeled with a radioactive technetium or rhenium by a chelating ligand which is attached to the tropane ligand by a linker. Tropane compounds or ligands useful in the pratice of the present invention can generally be represented by formula II where R1 and R2 are defined as above and where R1 can also be substituted at the C4 position of the tropane ring: Any tropane compound of the general formula II is useful in the present invention so long as it binds to DAT. Useful tropane analogs have a 3α-group,i.e., are of the boat configuration. Intermediates for the synthesis of the radiolabeled tropanes are claimed.
3-Aryl-2-carbomethoxybicyclo[3.2.1]oct-2-enes inhibit WIN 35,428 binding potently and selectively at the dopamine transporter
Meltzer, Peter C.,Blundell, Paul,Huang, Hong,Liu, Shanghao,Yong, Yaw F.,Madras, Bertha K.
, p. 581 - 590 (2007/10/03)
The search for medications for cocaine abuse has focused upon the design of potential cocaine antagonists or cocaine substitutes which interact at the dopamine transporter of mammalian systems. This manuscript describes the synthesis and biological evalua
