30675-13-9 Usage
Description
TCID (30675-13-9) inhibits ubiquitin C-terminal hydrolase L3 (UCH-L3). IC50=0.6 μM, 125-fold selective over UCH-L1, IC50=75 μM. Cell permeable.
Uses
TCID is a small molecule inhibitor of DNA polymerase λ.
References
1) Love et al. (2007), Mechanisms, biology and inhibitors of deubiquitinating enzymes; Nat. Chem. Biol., 3 697
2) Mtango et al. (2012), Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation; J. Cell Physiol., 227 2022
Check Digit Verification of cas no
The CAS Registry Mumber 30675-13-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,6,7 and 5 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 30675-13:
(7*3)+(6*0)+(5*6)+(4*7)+(3*5)+(2*1)+(1*3)=99
99 % 10 = 9
So 30675-13-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H2Cl4O2/c10-6-4-2(14)1-3(15)5(4)7(11)9(13)8(6)12/h1H2
30675-13-9Relevant articles and documents
Cyclopropanation of active methylene compounds with β-alkoxycarbonyl vinylsulfonium salts
Guo, Shenquan,Zhang, Niuniu,Tang, Xiangzheng,Mao, Zhifeng,Zhang, Xuejing,Yan, Ming,Xuan, Yining
supporting information, p. 406 - 408 (2018/09/25)
An efficient synthesis of β-alkoxycarbonyl vinylsulfonium salts had been developed. Their reaction with indene-1,3-diones and other active methylene compounds provided cyclopropane carboxylates in good yields. A tentative reaction mechanism was proposed.
Studies on substances having antiviral activity. Thiosemicarbazones of indandione, cyclopentenediones and pentanediones
Giannella,Gualtieri,Melchiorre,Pigini
, p. 597 - 610 (2007/10/09)
In order to evaluate the effect of structural modifications on antiviral activity of the dithiosemicarbazones of 1,3 indandione and 2 hydroxyimino 1,3 indandione, several derivatives of substituted 1,3 indandiones, 4 cyclopenten 1,3 diones and 2,4 pentand
