306936-02-7

Basic information

• Product Name: 3-[4-(TRIFLUOROMETHOXY)PHENYL]PROP-2-ENOYL CHLORIDE
• Synonyms: BUTTPARK 96\50-34;3-[4-(TRIFLUOROMETHOXY)PHENYL]PROP-2-ENOYL CHLORIDE;3-[4-(Trifluoromethoxy)phenyl]acryloyl chloride, 3-[4-(Trifluoromethoxy)phenyl]prop-2-enoyl chloride;3-[4-(Trifluoromethoxy)phenyl]cinnamoyl chloride
• CAS NO: 306936-02-7
• Molecular Formula: C₁₀H₆ClF₃O₂
• Molecular Weight: 250.6
• Mol File: 306936-02-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 86°C 0,8mm
• Flash Point: 110.9°C
• Appearance: /
• Density: 1.397g/cm³
• Vapor Pressure: 0.00468mmHg at 25°C
• Refractive Index: 1.515
• CAS DataBase Reference: 3-[4-(TRIFLUOROMETHOXY)PHENYL]PROP-2-ENOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(TRIFLUOROMETHOXY)PHENYL]PROP-2-ENOYL CHLORIDE(306936-02-7)
• EPA Substance Registry System: 3-[4-(TRIFLUOROMETHOXY)PHENYL]PROP-2-ENOYL CHLORIDE(306936-02-7)

Safety Data

• Hazard Codes: C:Corrosive
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• Hazardous Substances Data: 306936-02-7(Hazardous Substances Data)

Usage

Properties

It is a chlorinated acyl chloride derivative.
Contains a trifluoromethoxy group on the phenyl ring.

Common Uses

Used in organic synthesis as a building block for various pharmaceuticals, agrochemicals, and materials.
Acts as a reagent in the synthesis of fluorinated organic compounds.

Specific Content

Contains a phenyl group substituted with a trifluoromethoxy group at the 4-position.
Has a prop-2-enoyl chloride functional group at the 3-position.

Unique Properties

The trifluoromethoxy group introduces unique electronic and steric properties.
Useful in developing new chemical entities with improved pharmacological and physical properties.

Safety Considerations

Due to its reactivity and potential hazards, it should be handled with caution.
Follow established safety protocols when working with this compound.

InChI:InChI=1/C10H6ClF3O2/c11-9(15)6-3-7-1-4-8(5-2-7)16-10(12,13)14/h1-6H/b6-3+

Upstream product

• 783-13-1 4-trifluoromethoxycinnamic acid 

Relevant articles and documents

Prodrugs of N-dicarboximide derivatives of the rat selective toxicant norbormide

Norbormide [5-(α-hydroxy-α-2-pyridylbenzyl)-7-(α-2- pyridylbenzylidene)-5-norbornene-2,3-dicarboximide] (NRB), an existing but infrequently used rodenticide, is known to be uniquely toxic to rats but relatively harmless to other rodents and mammals. However, one major drawback of NRB as a viable rodenticide relates to an evolutionary aversion developed by the rat leading to sub-lethal dosing due to either its unpleasant 'taste' or rapid onset of effects. A series of NRB-derived prodrugs were prepared in an effort to 'mask' this acute response. Their synthesis and biological evaluation (in vitro vasoconstrictory activity, in vitro hydrolytic and enzymatic stability and lethality/palatability in vivo) is described. Prodrug 2 displayed the most promising profile with respect to a delay in the onset of symptoms and was subsequently demonstrated to be significantly more palatable to rats. Moreover, prodrug 25 was found to be largely accepted by rats in a choice trial, resulting in high mortality.