306960-74-7

Usage

Uses

Used in Chemical Research:
2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLIC ACID is used as a research compound for studying the properties and reactivity of trifluoromethyl-substituted pyrimidines. Its unique structure allows for the investigation of various chemical reactions and the development of new synthetic pathways.
Used in Pharmaceutical Industry:
2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLIC ACID is used as a building block for the synthesis of various pharmaceutical compounds, particularly those with potential insecticidal properties. Its incorporation into anthranilic diamides can lead to the development of new insecticides with improved efficacy and selectivity.
Used in Insecticide Development:
In the agricultural industry, 2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLIC ACID is used as a key component in the development of insecticidal anthranilic diamides. These compounds have shown potential in controlling pests and protecting crops from damage, making them valuable tools in modern agriculture.

InChI:InChI=1/C6H3F3N2O2/c7-6(8,9)5-10-1-3(2-11-5)4(12)13/h1-2H,(H,12,13)

Upstream product

• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 
• 71043-33-9 Methylmethoxymethylenacetoacetat 
• 915376-16-8 4-methyl-2-trifluoromethyl-pyrimidine-5-carboxylic acid methyl ester 
• 306960-67-8 ethyl 4-methyl-2-(trifluoromethyl)pyrimidine-5-carboxylate 

Downstream Products

• 362636-72-4 4-methyl-N-[2-methyl-6-[[(1-methylethyl)amino]carbonyl]phenyl]-2-(trifluoromethyl)-5-pyrimidinecarboxamide 

Relevant academic research and scientific papers

halogen-substituted compounds

The invention relates to compounds of the general formula (I), in which the radicals A1, A2, A3, A4, Lm, Q, R1, T and U have the meaning given in the description and to the use of the compounds for controlling animal pests. In addition, the invention relates to processes and intermediates for the preparation of the compounds according to formula (I).

Dpp-IV inhibitors

The invention relates to compounds of formula (I) wherein R1, R2, R3 and n have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV inhibitors. The invention also relates to the prep

Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators

A novel class of anthranilic diamides has been discovered with exceptional insecticidal activity on a range of Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. The discovery, synthesis, structure-activity, and biological results are presented.

Inhibitors of NF-kappaB and AP-1 gene expression: SAR studies on the pyrimidine portion of 2-chloro-4-trifluoromethylpyrimidine-5-[N-(3', 5'-bis(trifluoromethyl)phenyl)carboxamide].

We investigated the structure-activity relationship studies of N-[3, 5-bis(trifluoromethyl)phenyl][2-chloro-4-(trifluoromethyl)pyrimidin-5 -yl]carboxamide (1), an inhibitor of transcription mediated by both NF-kappaB and AP-1 transcription factors, with the goal of improving its potential oral bioavailability. Compounds were examined for cell-based activity, were fit to Lipinski's rule of 5, and were examined for potential gastrointestinal permeability using the intestinal epithelial cell line, Caco-2. Selected groups were substituted at the 2-, 4-, and 5-positions of the pyrimidine ring using solution-phase combinatorial methodology. The introduction of a fluorine in the place of 2-chlorine of 1 resulted in a compound with comparable activity. However, other substitutions at the 2-position resulted in a loss of activity. The trifluoromethyl group at the 4-position could be replaced with a methyl, ethyl, chlorine, or phenyl without a substantial loss of activity. The carboxamide group at the 5-position is critical for activity. If it was moved to the 6-position, the activity was lost. The 2-methyl analogue of 1 (81) showed comparable in vitro activity and improved Caco-2 permeability compared to 1.