306965-33-3Relevant academic research and scientific papers
β-oxoacids esters in the synthesis of benzo[f]quinoline derivatives
Gusak,Kozlov
, p. 706 - 718 (2008/02/08)
Condensation of ethyl acetoacetate and ethyl 3-oxo-3-(2-furyl-, 2-quinolyl-, 3-pyridyl)propanoates with azomethines of 2-naphthylamine series led to the formation of ethyl (3-arylbenzo[f]quinol-1-yl)acetates and of esters of the corresponding 3-aryl-1-heteryl-2-benzo[f]quinolylcarboxylic acids. The intermediate reaction products were isolated: ethyl 5-(2-naphthylamino)-3-oxo-5- phenylpentanoate, 2-[(aryl)(2-naphthylamino)methyl]-3-heteryl-3-oxopropanoates, dihydro and tetrahydro derivatives of benzoquinolylacetic and benzoquinolinecarboxylic acids. Nauka/Interperiodica 2007.
Synthesis of benzo[f]quinoline derivatives by condensation of arylmethylene-2-naphthylamines with ethyl acetoacetate
Kozlov,Sauts,Gusak
, p. 531 - 538 (2007/10/03)
Reaction of arylmethylene-2-naphthylamines with ethyl acetoacetate affords ethyl (3-arylbenzo-[f]quinol-1-yl)acetates. On boiling thereof with ethanol solutions of alkali arise the corresponding salts that when treated with mineral acids undergo decarboxylation to yield 3-aryl-1-methylbenzo[f]quinolines. Heating of ethyl (3-arylbenzo[f]quinol-1-yl)acetates with dimethyl sulfate gives rise to 3-aryl-4-methyl-1-ethoxycarbonylmethylbenzo[f]quinolinium methylsulfates which afford the corresponding perchlorates after treatment with HClO4.
