306974-39-0Relevant academic research and scientific papers
MANGANESE-CATALYSED HYDROGENATION OF ESTERS
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Page/Page column 34; 42, (2019/08/06)
The present invention relates to the field of catalytic hydrogenation and, more particularly, to methods of manganese-catalysed hydrogenation of esters to alcohols. Advantageously, where the esters are chiral, the hydrogenations proceed with high or complete stereochemical integrity..
Manganese Catalyzed Hydrogenation of Enantiomerically Pure Esters
Widegren, Magnus B.,Clarke, Matthew L.
supporting information, p. 2654 - 2658 (2018/05/17)
A manganese-catalyzed hydrogenation of esters has been accomplished with TONs up to 1000, using cheap, environmentally benign, potassium carbonate and simple alcohols as activator and solvent, respectively. The weakly basic conditions lead to good functional group tolerance and enable the hydrogenation of enantiomerically enriched α-chiral esters with essentially no loss of stereochemical integrity.
Ru-catalyzed asymmetric hydrogenation of racemic aldehydes via dynamic kinetic resolution: Efficient synthesis of optically active primary alcohols
Xie, Jian-Hua,Zhou, Zhang-Tao,Kong, Wei-Ling,Zhou, Qi-Lin
, p. 1868 - 1869 (2007/10/03)
A highly efficient asymmetric hydrogenation of racemic α-arylaldehydes via dynamic kinetic resolution has been developed by using [RuCl2(SDPs)(diamine)] complexes as catalysts, providing chiral primary alcohols in excellent enantioselectivities. Copyright
Chiral α-substituted carbonyls and alcohols from the S(N)2' displacement of cuprates on chiral carbonates: An alternative to the alkylation of chiral enolates
Spino,Beaulieu,Lafreniere
, p. 7091 - 7097 (2007/10/03)
A highly stereoselective sequence of reactions, based on the anti-selective S(N)2' addition of cuprates to allylic carbonates, transforms alkynes or alkenyl halides into carbonyls having α-chiral centers. The method, which uses menthone as a chiral auxiliary, is a useful alternative to the alkylation of chiral enolates with the added advantage of allowing for the 'alkylation' of sec- and tert-alkyl and aryl groups.
