306993-99-7

Upstream product

• 64-17-5 ethanol 
• 728-97-2 2-[(4-methylphenoxy)methyl]benzoic acid 
• 106-44-5 p-cresol 
• 87-41-2 2-benzofuran-1(3H)-one 

Downstream Products

• 1257524-55-2 2-(4-methylphenoxymethyl)benzoyl hydrazide 
• 1282001-62-0 6-(5-chloro-2-sulfonamidothien-3-yl)-3-[2-(2-methylphenoxymethyl)phenyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 1282001-66-4 6-(3-bromophenyl)-3-[2-(4-methylphenoxymethyl)phenyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 1282001-54-0 C₂₅H₂₁N₅O₃S 
• 1282001-74-4 C₂₄H₁₉N₅O₃S 

Relevant academic research and scientific papers

Synthesis and biological evaluation of some [1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines

The reaction of 2-(aryloxymethyl)benzoic acid hydrazide with carbon disulfide in the presence of potassium hydroxide followed by hydrazine hydrate afforded 4-amino-3{2-(aryloxymethyl)pheny}[1,2,4]triazole-5-thiol (5a-d). The cyclo-condensation of 5a-d with various aromatic carboxylic acids in the presence of phosphorous oxychloride and with phenacyl bromides afforded two series of fused heterocycles namely; 6-substituted-3-{2-(aryloxymethyl)phenyl}- 1,2,4- triazolo[3,4-b][1,3,4]thiadizoles (6a-t) and 6-substituted-3-{2- (aryloxymethyl)phenyl)}[1,2,4]triazolo[3,4-b][1,3,4] thiadiazines (7a-p) respectively. The structures of these newly synthesized compounds were established on the basis of their IR, 1H-NMR 13C-NMR and Mass spectral data. All the title compounds were screened for their antimicrobial and antiinflammatory activities. Preliminary results indicated that some of them exhibit promising activities and they deserve more consideration as potential antimicrobial and anti-inflammatory agents.

Synthesis, characterization and antimicrobial activity of some disubstituted 1,3,4-oxadiazoles carrying 2-(aryloxymethyl)phenyl moiety

Disubstituted 1,3,4-oxadaiazoles (4a-z, 4a′-f′), Mannich bases (6a-p) and S-alkylated derivatives (7a-t) have been synthesized from 2-(aryloxymethyl)benzoic acids (1a-d) through a multi-step reaction sequence. The structures of new compounds were established on the basis of their elemental analyses, IR, 1H NMR, 13C NMR and mass spectral data. All the synthesized compounds were screened for their in vitro antibacterial and antifungal activity and some of them exhibited good activity.