3072-13-7

Usage

Uses

Used in Pharmaceutical Industry:
LINOLEAMIDE is used as a sleep aid for its ability to induce sleep by mimicking the effects of naturally occurring lipids in the body. This makes it a valuable compound for the development of medications aimed at improving sleep quality and addressing sleep disorders.
Used in Cosmetics Industry:
LINOLEAMIDE is used as an ingredient in cosmetics for its emollient and skin-conditioning properties. It helps to maintain skin hydration and improve the overall texture and appearance of the skin, making it a popular choice for skincare products.
Used in Food Industry:
LINOLEAMIDE can be used as an additive in the food industry due to its fatty amide nature, which may contribute to the texture and stability of certain food products. However, its specific applications in this industry would depend on further research and regulatory approval.

Upstream product

• 7459-33-8 linoleyl chloride 
• 60-33-3 linoleic acid 
• 77287-34-4 formamide 
• 7619-08-1 octadeca-9,12-dienoic acid ethyl ester 

Downstream Products

• 25876-34-0 (9Z,12Z)-octadecane-9,12-dien-1-amine 

Relevant academic research and scientific papers

A Convenient Protocol for the Synthesis of Fatty Acid Amides

Several classes of biologically occurring fatty acid amides have been reported from mammalian and plant sources. Many amides conjugated with fatty acids of mammalian origin exhibit specific activation of individual receptors. Their potential as pharmacological tools or as lead compounds towards the development of novel therapeutics is of great interest. Hence, access to such amides by a practical, high-yielding and scalable protocol without affecting the geometry or position of sensitive functionalities is needed. A protocol that meets all these requirements involves activation of the corresponding acid with carbonyl diimidazole (CDI) followed by reaction with the desired amine or its hydrochloride. More than fifty compounds have been prepared in generally high yields.

Acyl-CoA: Cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas

Unsaturated fatty acid amides, 9(Z)-octadecenamide (2) and 9(Z),12(Z)-octadecadienamide (4) as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT) were isolated from the ethyl acetate extracts of the insect, Mylabris phalerate Pallas, and elucidated by their spectroscopic data analysis. Compounds 2 and 4 inhibited rat liver microsomal ACAT, hACAT-1, and hACAT-2 with IC50 values of 170, 85, and 63μM for 2 and of 151, 53, and 45μM for 4, respectively.

The invention of radical reactions. Part XXIII new reactions: Nitrile and thiocyanate transfer to carbon radicals from sulfonyl cyanides and sulfonyl isothiocyanates

Reaction of p-toluenesulphonyl cyanide or methanesulfonyl cyanide with carbon radicals, generated from the corresponding O-acyl-N-hydroxy-2-thiopyridone derivatives by visible light photolysis gives nitriles in good yield. The homolysis products of these sulfonyl nitriles can also be trapped by electron rich olefins. We have also found that carbon radicals react easily with mesyl or tosyl isothiocyanate producing thiocyanates.