307301-92-4

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 21921-76-6 4-bromo-2-furancarbaldehyde 
• 141-82-2 malonic acid 
• 765938-14-5 4-(4-methylphenyl)furan-2-carbaldehyde 

Downstream Products

• 1026076-23-2 3-(4-p-tolyl-furan-2-yl)-acryloyl chloride 

Relevant academic research and scientific papers

Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3- benzoylphenyl)-3-arylfurylacrylic acid amides

We have designed arylfurylacryl-substituted benzophenones as non-thiol farnesyltransferase inhibitors utilizing a novel aryl binding site of farnesyltransferase. These compounds display activity in the low nanomolar range. We have designed arylfurylacryl-

Structure-activity relationships of novel anti-malarial agents part 8. Effect of different central aryls in biarylacryloylaminobenzophenones on antimalarial activity

Replacement of the 2,5-disubstituted furyl residue present in the known antimalarial agents 8 by other aryl residues resulted in a more or less reduced antimalarial activity in most cases. The only exemption was the 2,4-thienylene compound 11a displaying activity with an IC50 value of 120 nM. In conclusion, the 2,5-furylene compound 8e remains to represent the most active antimalarial agent in this series of farnesyltransferase inhibitors.