307316-14-9

Basic information

• Product Name: Butanoic acid, 4-amino-2-chloro-, (2R)-
• CAS NO: 307316-14-9
• Molecular Formula: C4H8ClNO2
• Molecular Weight: 137.566
• Mol File: 307316-14-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4-amino-2-chloro-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-amino-2-chloro-, (2R)-(307316-14-9)
• EPA Substance Registry System: Butanoic acid, 4-amino-2-chloro-, (2R)-(307316-14-9)

Safety Data

• Hazardous Substances Data: 307316-14-9(Hazardous Substances Data)

Downstream Products

• 2133-34-8 (2S)-azetidine-2-carboxylic acid 
• 352018-64-5 (R)-4-N-(p-toluenesulfonyl)amino-2-chlorobutyric acid 

Relevant articles and documents

PROCESS FOR PRODUCING OPTICALLY ACTIVE AZETIDINE-2-CARBOXYLIC ACIDS

An optically active N-protected azetidine-2-carboxylic acid (5) can be produced by preparing an optically active 4-amino-2-halobutyric acid (3), ???by halogenating an optically active 3-hydroxy-2-pyrrolidinone (1) with inversion of configuration to prepare an optically active 3-halo-2-pyrrolidinone (2) followed by hydrolysis or, ???by halogenating an optically active 4-amino-2-hydroxybutyric acid ester (6) with inversion of configuration to prepare an optically active 4-amino-2-halobutyric acid ester (7) followed by hydrolysis or, ???by halogenating the compound (6) with inversion of configuration to prepare the compound (7), cyclizing the same to prepare the compound (2) followed by hydrolysis,???further cyclizing the compound (3) followed by treating the reaction product with an amino group-protecting agent.The optical purity of the thus-obtained compound (5) can be improved further by recrystallization.