307343-41-5Relevant academic research and scientific papers
Synthesis and characterization of 5-heteroarylsulfanyl-4-aryl- 1,2,3-selena/thiadiazoles
Manikannan, Ramaiyan,Shanmugaraja, Masilamani,Manojveer, Seetharaman,Muthusubramanian, Shanmugam
, p. 463 - 468 (2012)
Synthesis and spectral characterization of 2-methyl-5-[(4-aryl-1,2,3- selenadiazol-5-yl)sulfanyl]-1,3,4-thiadiazoles, 5-[4-aryl-1,2,3-selenadiazol-5- yl]sulfanyl-1-phenyl-1H-1,2,3,4-tetraazoles, 4-aryl-5-[(5-methyl-1,3,4- thiadiazol-2-yl)sulfanyl]-1,2,3-t
Synthesis of 1,3,4-thiadiazol-2(3H)-one derivatives via an unexpected intramolecular addition-elimination reaction of 1,3,4-thiadiazoles
Tahtaci, Hakan,Er, Mustafa,Karakurt, Tuncay,Sancak, Kemal
, p. 4418 - 4425 (2017/06/30)
A new synthesis was developed for 1,3,4-thiadiazol-2(3H)-one derivatives, based on a new arrangement on the thiadiazole ring with an intramolecular addition-elimination reaction. To this end, starting from 5-methyl-1,3,4-thiadiazole-2-thiol (1), derivatives of 3-((un)substituted benzyl)-5-methyl-1,3,4-thiadiazol-2(3H)-one (7a-g) and ((un)substituted phenyl)-2-oxoethyl)-5-methyl-1,3,4-thiadiazol-2(3H)-one (10–15) were synthesized (in yields of 81–88% and 63–71%, respectively). The structures of all synthesized compounds were characterized using IR, 1H NMR, and 13C NMR spectroscopy, and elemental analysis, mass spectroscopy and X-ray diffraction analysis (compounds 3c, 7b-f and 10) techniques. This study presents a new and effective reaction path for the synthesis of 1,3,4-thiadiazol-2(3H)-one derivatives.
