307344-42-9Relevant academic research and scientific papers
Concise and stereocontrolled synthesis of polysubstituted tetrahydropyrans
Marko,Leroy
, p. 7225 - 7230 (2000)
A range of polysubstituted tetrahydropyrans can be readily assembled by a novel methodology involving a metallo-ene reaction coupled with an intramolecular Sakurai cyclisation (IMSC). (C) 2000 Elsevier Science Ltd.
Connective synthesis of polysubstituted tetrahydropyrans by a novel and stereocontrolled metallo-ene/Intramolecular Sakurai Cyclization sequence
Leroy, Bernard,Marko, Istvan E.
, p. 8744 - 8752 (2007/10/03)
A novel methodology based upon the allylmetalation step followed by an Intramolecular Sakurai Cyclization (IMSC) provides an efficient access to a variety of tetrahydropyran derivatives. This new strategy nicely complements our initial protocol that embodied a tandem ene reaction/IMSC sequence. Both mono- and dihydroxy-tetrahydropyrans could be easily assembled with complete stereocontrol at the various chiral centers.
