307353-90-8 Usage
Uses
Used in Pharmaceutical Synthesis:
4-Chloro-6-methoxy-7-(phenylmethoxy)-3-quinolinecarboxylic acid ethyl ester is used as a building block for the synthesis of pharmaceuticals due to its versatile reactivity and ability to modulate biological activities. Its structural features and pharmacological properties make it a promising candidate for the development of new drugs in the field of medicinal chemistry and drug discovery.
Used in Agrochemical Synthesis:
In the agrochemical industry, 4-Chloro-6-methoxy-7-(phenylmethoxy)-3-quinolinecarboxylic acid ethyl ester is used as a building block for the synthesis of agrochemicals. Its unique structural features and reactivity contribute to the development of effective and targeted agrochemical products.
Used in Organic Reactions:
The ethyl ester form of 4-Chloro-6-methoxy-7-(phenylmethoxy)-3-quinolinecarboxylic acid makes it suitable for use in various organic reactions. It can be employed as a precursor for the preparation of other ester derivatives, further expanding its applications in organic chemistry.
Used in Medicinal Chemistry and Drug Discovery:
4-Chloro-6-methoxy-7-(phenylmethoxy)-3-quinolinecarboxylic acid ethyl ester has potential applications in the field of medicinal chemistry and drug discovery. Its structural features and pharmacological properties make it a valuable compound for the development of new therapeutic agents and the exploration of novel biological targets.
Check Digit Verification of cas no
The CAS Registry Mumber 307353-90-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,7,3,5 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 307353-90:
(8*3)+(7*0)+(6*7)+(5*3)+(4*5)+(3*3)+(2*9)+(1*0)=128
128 % 10 = 8
So 307353-90-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H18ClNO4/c1-3-25-20(23)15-11-22-16-10-18(17(24-2)9-14(16)19(15)21)26-12-13-7-5-4-6-8-13/h4-11H,3,12H2,1-2H3
307353-90-8Relevant academic research and scientific papers
Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase
Scott, David A.,Balliet, Carrie L.,Cook, Donald J.,Davies, Audrey M.,Gero, Thomas W.,Omer, Charles A.,Poondru, Srinivasu,Theoclitou, Maria-Elena,Tyurin, Boris,Zinda, Michael J.
scheme or table, p. 697 - 700 (2009/08/15)
3-Amido-4-anilinoquinolines are potent and highly selective inhibitors of CSF-1R. Their synthesis and SAR is reported, along with initial efforts to optimize the physical properties and PK through modifications at the quinoline 6- and 7-positions.
Derivatives of quinoline as inhibitors for MEK
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Page/Page column 41, (2010/02/14)
1. A compound of formula (I) or a pharmaceutically acceptable salt thereof. wherein: n is 0-1; X and Y are independently selected from -NH-, -O-, -S-, or -NR8- where R8 is alkyl of 1-6 carbon atoms and X may additionally comprise a CH2 group; R7 is a group (CH2)mR9 where m is 0,or an integer of from 1-3 and R9 is a substituted aryl group, an optionally substituted cycloalkyl ring of up to 10 carbon atoms, or an optionally substituted heterocyclic ring or an N-oxide of any nitrogen containing ring; R6 is a divalent cycloalkyl of 3 to 7 carbon atoms, which may be optionally further substituted with one or more alkyl of 1 to 6 carbon atom groups; or is a divalent pyridinyl, pyimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally further substituted with one or more specified groups; R1, R2, R3 and R4 are each independently selected from hydrogen or various specified organic groups. Compounds are useful as pharmaceuticals for the inhibition of MEK activity.
