30739-35-6Relevant academic research and scientific papers
Selective iodine-catalyzed intermolecular oxidative amination of C(sp 3)-H bonds with ortho-carbonyl-substituted anilines to give quinazolines
Yan, Yizhe,Zhang, Yonghui,Feng, Chengtao,Zha, Zhenggen,Wang, Zhiyong
supporting information; experimental part, p. 8077 - 8081 (2012/08/29)
Access to quinazolines: The selective amination of C(sp3)-H bonds adjacent to nitrogen or oxygen atoms of N-alkylamides, ethers, or alcohols with ortho-carbonyl-substituted anilines constitutes the first step in a tandem annulation that leads to quinazolines in good to excellent yields (see scheme; NIS=N-Iodosuccinimide, TBHP=tert-butyl hydroperoxide). The selectivity of the amination of primary and secondary C-H bonds is also noteworthy (left: >3:1, right: >99:1). Copyright
