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Isocolchicine is a minor alkaloid found in the corms and seeds of Colchicum autumnale, Gloriosa virescens, and Littoria modesta. It is a levo-rotatory compound with a specific rotation of [α]D 307° (CHCI3). Isocolchicine can be separated from the numerous accompanying bases by column and thin layer chromatography.

30771-10-9

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30771-10-9 Usage

Uses

Used in Pharmaceutical Industry:
Isocolchicine is used as an active pharmaceutical ingredient for its anti-inflammatory and immunosuppressive properties. It is particularly effective in treating gout, Familial Mediterranean Fever (FMF), and certain autoimmune diseases.
Used in Research Applications:
In the field of research, isocolchicine is used as a tool compound to study the effects of microtubule dynamics on cellular processes. It binds to tubulin, a protein subunit of microtubules, and inhibits microtubule polymerization, which can provide insights into various cellular functions and potential therapeutic targets.
Used in Drug Development:
Isocolchicine serves as a lead compound in the development of new drugs targeting microtubule dynamics. Its unique interaction with tubulin makes it a valuable starting point for designing novel therapeutic agents with improved efficacy and reduced side effects.
Used in Analytical Chemistry:
In analytical chemistry, isocolchicine can be used as a reference compound for the development and validation of chromatographic methods, such as column and thin layer chromatography, for the separation and identification of alkaloids in various plant extracts.

References

Potesilova, Hrbek, Santavy, Collect. Czech. Chem. Commun., 32, 141 (1967)

Check Digit Verification of cas no

The CAS Registry Mumber 30771-10-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,7,7 and 1 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 30771-10:
(7*3)+(6*0)+(5*7)+(4*7)+(3*1)+(2*1)+(1*0)=89
89 % 10 = 9
So 30771-10-9 is a valid CAS Registry Number.
InChI:InChI=1/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-17(25)18(26-2)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)

30771-10-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(1,2,3,9-tetramethoxy-10-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide

1.2 Other means of identification

Product number -
Other names Iso-Colchicin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:30771-10-9 SDS

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