30784-65-7

Basic information

• Product Name: 3',5'-di-O-acetyl-N⁶-benzoyl-2'-deoxyadenosine
• Synonyms: 3',5'-di-O-acetyl-N⁶-benzoyl-2'-deoxyadenosine
• CAS NO: 30784-65-7
• Molecular Weight: 439.428
• Mol File: 30784-65-7.mol

Chemical Properties

• CAS DataBase Reference: 3',5'-di-O-acetyl-N⁶-benzoyl-2'-deoxyadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-di-O-acetyl-N⁶-benzoyl-2'-deoxyadenosine(30784-65-7)
• EPA Substance Registry System: 3',5'-di-O-acetyl-N⁶-benzoyl-2'-deoxyadenosine(30784-65-7)

Safety Data

• Hazardous Substances Data: 30784-65-7(Hazardous Substances Data)

Upstream product

• 114762-37-7 Acetic acid (2R,3S)-2-acetoxymethyl-5-fluoro-tetrahydro-furan-3-yl ester 
• 18055-47-5 N-Benzoyl-N,9-bis(trimethylsilyl)adenin 
• 55-21-0 benzamide 
• 385806-26-8 9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-6-bromopurine 
• 108-24-7 acetic anhydride 
• 51549-41-8 N⁶-benzoyl-O^3'_,O5'-bis-(tert-butyl-dimethyl-silanyl)-2'-deoxy-adenosine 

Relevant articles and documents

Transprotection of silyl ethers of nucleosides in FeCl3 based ionic liquids

Ionic liquid mediated deprotection of tert-butyldimethyl silyl (TBDMS) ethers derived from various primary and secondary alcohols have been studied and the reaction conditions optimized. Deprotection of the silyl ethers in FeCl3 based ionic liquids in presence of acetic anhydride yielded the acetate esters of the corresponding alcohols in good yields. The transprotection methodology was extended to the silyl ethers of nucleosides to yield the corresponding acetylated products. Copyright Taylor & Francis, Inc.

A direct, efficient method for the preparation of N6-protected 15N-labeled adenosines

N6-Protected adenosines have been prepared from inosines by activation of the C6 position and Pd-catalyzed coupling with amides. An efficient route to [6-15-NH2]-N6- benzoyladenosine and [1-15N,6-15NH2]-N 6-benzoyladenosine has been achieved.

Protected deoxyadenosines and deoxyguanosines

Processes are disclosed for the preparation of either an N-acyl deoxyadenosine or an N-acyl deoxyguanosine by acylating the hydroxyl groups and the exocyclic amino group of a corresponding deoxyadenosine or deoxyguanosine with anhydride to form a 3′-, 5′-O-acyl, N-acyl deoxyneucloside and then selectively removing the acyl groups from the hydroxyl groups to form an N-acyl deoxyadenosine or N-acyl deoxyguanosine.

Condensation of 1-Fluorofuranones and Silylated Nucleobases Catalyzed by Tetrafluorosilane

The title reaction provides a generally useful tool for nucleoside synthesis.The stereoselectivities are highly influenced by the fluoride substrates, and steric course of the reaction of O-benzylated ribofuranosyl fluoride is solvent dependent.