307952-36-9Relevant academic research and scientific papers
trans-1-[(2-phenylcyclopropyl)methyl]-4-arylpiperazines: Mixed dopamine D2/D4 receptor antagonists as potential antipsychotic agents
Zhang,Hodgetts,Rachwal,Zhao,Wasley,Craven,Brodbeck,Kieltyka,Hoffman,Bacolod,Girard,Tran,Thurkauf
, p. 3923 - 3932 (2000)
The dopaminergic receptor profile of a series of trans-1-[(2-phenylcyclopropyl)methyl]-4-arylpiperazines was examined. Aromatic substitution patterns were varied with the goal of identifying a compound having affinities for the D2 and D4 receptors in a ratio similar to that observed for the atypical neuroleptic clozapine. The compounds (1S,2S)-trans-1-[(2-phenylcyclopropyl)methyl]-4-(2,4-dichlorophenyl)piperazin e (5m) and (1S,2S)-trans-1-[(2-phenylcyclopropyl)methyl]-4-(2,4-dimethylphenyl)piperazin e (5t) were selected for functional antagonists at D2 and D4 receptors and had a D2/D4 ratio approximating that of clozapine; they proved inactive in behavioral tests of antipsychotic activity.
