307953-36-2

Upstream product

• 75-07-0 acetaldehyde 
• 307953-32-8 33-(tert-butyldimethylsilyl)-24-deoxy-22-dihydro-22-triethylsilyl enol ether ascomycin 
• 142498-46-2 12-{2-[4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-1-methyl-vinyl}-17-ethyl-1-hydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0^4,9]octacosa-14,18-diene-2,3,10,16-tetraone 
• 133941-74-9 33-O-(tert-butyldimethylsilyl)-ascomycin 

Relevant academic research and scientific papers

Regioselective carbon-carbon bond formation in the effector domain of ascomycin

Starting from 33-O-silyl-protected ascomycin or its 23,24-dehydration product, regio- and stereo-selective formal aldol reactions under carbon-carbon bond formation at C-22, C-23, or C-24 are demonstrated. Additionally, with the 22-silyl enol ether ascomycin derivative a rhodium(I)-catalysed shift of the 19,20 double bond into the 19,38 exocyclic position is observed at elevated temperature. (C) 2000 Elsevier Science Ltd.