308085-14-5

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 616-34-2 methoxycarbonylmethylamine 

Downstream Products

• 1310430-64-8 (2R,4S,5R)-dimethyl 5-((E)-styryl)pyrrolidine-2,4-dicarboxylate 
• 1544337-33-8 (1S,6R,7R,9S)-methyl 5-benzoyl-9-((E)-styryl)-8-azabicyclo[4.3.1]deca-2,4-diene-7-carboxylate 
• 213883-22-8 ((3S,4R)-3-tert-Butoxycarbonylamino-2-oxo-4-phenethyl-azetidin-1-yl)-acetic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of decahydropyrrolo[2,1,5-cd]indolizine derivatives through RuCl3/AgOTf induced alkene-alkene and alkene-arene double cycloisomerizations

In the presence of RuCl3/AgOTf, pyrrolizidine derivative with styrenyl substituents at the 3,5-positions undergo a 6-exo-trig cyclization and subsequent intramolecular Friedel-Crafts reactions to form decahydropyrrolo[2,1, 5-cd]indolizine or de

Application of the Barton photochemical reaction in the synthesis of 1-dethia-3-aza-1-carba-2-oxacephem: A novel agent against resistant pathogenic microorganisms

Racemic 7-(phenylacetamido)-1-dethia-3-aza-1-carba-2-oxacephem 3 was synthesized and found to possess antibacterial activity against Staphylococcus aureus PDA 209P, Escherichia coli ATCC 39188, Pseudomonas aeruginosa 1101-75 and Klebsiella pneumoniae NCTC 418 as well as the β-lactamase producing organisms E. coli A9675 and P. aeruginosa 18S-H and the methicillin-resistant organism S. aureus 95. Formation of the carbacephem 3 originated from the Barton photochemical reaction in the conversion of 8 to 10. Intramolecular cyclization of syn-oximino β-lactam 10 afforded 7-azido-2-oxa-3-azacephem 11, which was reduced and acylated to 12. Enzymatic removal of the methyl group from 12 gave the target molecule 3.