308142-35-0Relevant academic research and scientific papers
Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists
Zhu, Yun-Fei,Struthers,Connors, Jr., Patrick J.,Gao, Yinghong,Gross, Timothy D.,Saunders, John,Wilcoxen, Keith,Reinhart, Greg J.,Ling, Nicholas,Chen, Chen
, p. 399 - 402 (2007/10/03)
Initial SAR studies on 1-aminomethyl-2-aryl-3-cyano-pyrrolo[1,2-a]pyrimid-7-one-6-carboxylates as human GnRH receptor antagonists were discussed. 2-(2-Methylaminoethyl)pyridine was discovered to be a key feature for generating active compounds. The best compound from the series had 25 nM (Ki) binding affinity to human GnRH receptor.
Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
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Page column 31, (2010/01/30)
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Ar, B, R1, R2, R3a, R3b, R4, R5, R6and m are as defined herein.
